The Midlands Black Rhino Conservancy (MBRC) is recognised as the second fauna and flora hot spot in Zimbabwe after Chirinda forest in the Eastern highlands. The safari is home to hundreds of other wildlife including zebra, giraffes, bushbucks, impala, kudu, waterbuck, eland, big cats and over 200 species of birds including African Fish Eagle, Hummerkop, Laughing Dove, Common Waxbill, Blue Waxbill, Quela, Francolin and Guinea Fowl, masked weavers, Red-eyed Bulbul and Grey African Hornbill. Also enclosed within the premises lies the picturesque Shorai Dam, which is  major source of water for both wildlife and aquatic life. This reservoir supports a rich variety of fish species which includes cat fish, bream and bass.

The MBRC is also famous for its Black Rhino species which the continent over has always been under threat due to poaching. A chromium mine located within the MBRC has increased vulnerability to the rhino population and numbers in this area. The MBRC was once a sanctuary of about 60 of these magnificent creatures. Today they are less than a quarter of the initial population .

The Nyangombe Safari Lodge for the past decade in strategic partnership with The  Midlands Black Rhino Conservancy exists  to advocate for nature conservation, promoting the protection of black  rhino, reducing habitat fragmentation and degradation, combating poaching attempts and ensuring their survival and growth, whilst also offering education, entertainment and thoughtful hospitality for the discerning visitor and eco tourist. Currently there are four fully grown rhinos on the safari.

Nyangombe Safari has a reasonable population of leopards. The lodge is popular sight for international hunters with a preference towards hunting this species. Since its establishment the safari has prioritised the preservation of these majestic cats. Together the MBRC and the Zimbabwe National Parks and Wildlife Authority (ZNPWA) have partnered to gather data to assess the behaviour of the leopards around the conservancy.